AKA: Acumen, Atrol, Bimanol, Cervoxan, dimethylaminoethanol pace-tamidobenzoate, Deaner, deanol, Difo-rene, Dimethaen, Dimethylaminoethanol, DMAE-H3, Elevan, Pabenol, Paxanol, Risatarun, Tonibral, Varesal.

Food Sources:
DMAE exists in tiny amounts in the brain and is found in such seafoods as anchovies, herring, and sardines. The prescription drug Deaner (deanol) is chemically similar.

Effects:
When combined with phosphatidyl choline and vitamin B-5, it produces acetylcholine, the neurotransmitter essential for short-term memory. It also removes the cellular aging pigment called lipofuscin, a waste product that may inhibit nerve cell functioning. There is some evidence it stabilizes the cell membranes of neurons, preventing one of the major factors of aging, the breakdown of neuronal membranes. It is similar in effect to centrophenoxine or Lucidril, in that it elevates mood, strengthens memory and learning, improves intelligence, lengthens the life span of lab animals (in one study, it lengthened the life span of mice 33-50 percent), reduces fatigue, produces sounder sleep, and decreases the amount of sleep needed. It can cross the blood/ brain barrier more readily than choline or lecithin, so an effective dosage is much lower than for the other two supplements, and it has a mild, steady stimulant effect which is said to lead to no letdown or side effects. No letdown or depression is experienced if use is discontinued.

Works synergistically with choline, Hydergine, Piracetam, Selegiline, and vasopressin, so lower doses should be taken if any of these supplements are also being taken.

Precautions:
People with manic-depression should not take DMAE, as it can worsen the depressive phase; those with epilepsy or seizure disorders should only do so under a physician’s guidance. Too high a dosage (at least 500 mg/day in some cases) can cause anxiety, nervousness, increased blood pressure, insomnia, dull headaches, or muscle tension (especially in the jaw, neck, and legs), which disappear if dosage is reduced. There are no known serious side effects or contraindications.

Dosage:
Gradually increase the dosage until it is around 500 to 1000 mg/day, though many people may respond well to lower dosages; one study recommends oral doses as low as 10 to 30 mg/day, which is enough to produce the desired effects. In general, older people can tolerate higher doses, either because they have lower levels of acetyl-choline, they may have reduced receptor sensitivity to acetylcholine, or they may have altered feedback in their brain metabolism. It may take up to three weeks before the effects are noticed. It should be stored in a cool, dark place, as it can deteriorate rapidly.